A new twist reveals how prostate cancer could start

prostate cancer cells. Credit: NIH Image Gallery

Researchers from the University of East Anglia have made an important discovery about how prostate cancer can begin to develop. A new study published today in Molecular Oncology reveals that the prostate as a whole, including normal-appearing cells, is different in men with prostate cancer. He suggests that tissue cells throughout the prostate are primed and ready to develop prostate cancer.

This means that it may be better to treat the entire prostate rather than just the areas of the prostate that have cancer. The team hopes their work will help scientists better understand the causes of prostate cancer and even prevent it altogether.

Lead researcher Professor Daniel Brewer of the Norwich Medical School of the UEA said: ‘Prostate cancer is the most common cancer in men and kills one man every 45 minutes in the UK.

“Often, when men are diagnosed with prostate cancer, clusters of cancer cells can be found in more than one location within the prostate. We wanted to know if this is due to changes in ‘normal’ prostate cells throughout the prostate. “.

Cancer is driven by changes in DNA, the genetic code of life, that appear in every cell. The team studied the DNA code in 121 tissue samples from 37 men with and without prostate cancer.

Professor Brewer said: ‘The samples we studied included tissue from cancer and tissue from other parts of the prostate, which look normal under the microscope.

“This produces a huge amount of data and by applying a great deal of computer power we can determine the differences that have occurred in the DNA, giving us information on how cancer grows. We found that” normal “prostate cells in men had prostate cancer had more mutations (changes in DNA) than “normal” prostate cells from men without prostate cancer.

“Based on the genetics of the samples we analyzed, we created maps to understand where the different mutations occurred. And we showed that in most men, mutations in normal cells are different from mutations in cancer cells.

“The ‘normal’ prostate cells in men who have prostate cancer appear to provide a beneficial environment for the development and growth of prostate cancer cells. In other words, the entire prostate is primed and ready to develop cancer. prostate guided by a not yet unknown biological process.

“This work has improved our understanding of how prostate cancer begins to develop and may someday give us clues as to how to prevent or treat it. And it shows that it may be better to treat the entire prostate rather than just the areas in the prostate that it has. cancer, “he added.

dr. Hayley Luxton, Senior Research Impact Manager at Prostate Cancer UK, said: “This exciting new research shows for the first time how normal prostate cells can facilitate the growth and spread of prostate cancer.

“Researchers found that normal prostate cells in men with prostate cancer have specific genetic changes that cause them to act as a rich compound, providing the perfect environment for prostate cancer cell growth and development. These results they provide us with important new information on the early development of prostate cancer, which may one day give us clues as to how to prevent it. ”

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More information:
The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates, Molecular Oncology (2022). DOI: 10.1186 / s12943-022-01644-3

Provided by the University of East Anglia

Citation: A New Breakthrough Reveals How Prostate Cancer Could Begin (2022, September 21) Retrieved September 21, 2022 from https://medicalxpress.com/news/2022-09-breakthrough-reveals-prostate-cancer.html

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