NFL Thanksgiving Schedule, Expert Picks, Odds and Predictions for all three games

Thanksgiving this year gives us a triple header with three good matchups. The Bills play the Lions in the first game of the day, and it will be the Bills’ second straight game in Detroit after the blizzard forced their Week 11 game in Detroit. The Bills are favored by more than one touchdown.

The second game features an NFC East battle between the Giants and Cowboys. Dallas is favored by more than one touchdown at home. The Giants hit their nadir of the season on Sunday when they lost to the Detroit Lions at home. The Cowboys had perhaps their best win of the season in a 40-3 blowout of the Vikings in Minnesota. Ezekiel Elliott also returned to the lineup and scored two touchdowns, while Tony Pollard had 180 yards from scrimmage and two touchdowns.

Minnesota hosts the Patriots in their final Thanksgiving game and is a favorite for field goals. The Vikings are 8-2 and have the second best record in the NFC, but they can’t feel good after being eliminated by the Cowboys. The Patriots beat the Jets on a last minute punt return touchdown in one of the ugliest games of the 2022 NFL season thus far.

NFL Thanksgiving Schedule 2022

  • Bills at Lions – 12:30 p.m. ET on CBS
  • Giants at Cowboys – 4:30 PM ET on FOX
  • Patriots at Vikings – 8:20 PM ET on NBC

All odds updates live. No teams are on standby this week.

Buffalo Bills to the Detroit Lions

After playing the “home” team in Detroit last week, the Bills will return to Ford Field on Thanksgiving to visit the Lions. Buffalo will be looking to win its second straight game and get back on track in the AFC playoff race and is favored by more than one touchdown against the Lions.

Kickoff is set for 12:30 ET Thursday from Detroit. The game will be broadcast on CBS.

There was a lot to like about Buffalo’s performance on Sunday if you’re a Bills fan, as they snapped their own two-game losing streak. Josh Allen eliminated turnovers from his game that were holding the team back in recent weeks as the rush pushed a poor Browns run defense to 171 yards, a 5.2 yard average per carry and a touchdown. Both Devin Singletary and James Cook went over the 80-yard mark in the win.

The only things holding the Bills back this season were Allen’s occasional turnover problem and a lack of production from their running backs. If they keep those two things in check, or at least limit Allen’s turnovers, they’ll be one of the toughest shutouts in the AFC playoffs.

They are still battling for first place in the AFC East and their remaining schedule is set for a frantic finish in the division. Four of the remaining seven games have come against AFC East foes (including both games against New England) and a potential first-place showdown with Miami. With Cincinnati remaining on the schedule, it’s going to be a tough ride for the rest, making games like Detroit the kind of games you can’t go wrong with.

But don’t sleep on Lions or think this is going to be a walkover game.

Dan Campbell has his team playing gutsy football, producing three-game hitting streak over Green Bay, Chicago, and a convincing win over the New York Giants on the road Sunday. They’ve played a lot of really good teams this season and have lost some tough games against Philadelphia, Minnesota, Seattle and Miami. Each of those four games was decided by four points or fewer.

It’s also an incredibly short and busy week for Buffalo. After going through whatever it took to get to Detroit for the rescheduled game, the Bills opted not to stay in Detroit. They returned to Buffalo for a couple nights before returning to Detroit for an early Thursday afternoon game. The road crews are already at a scheduling disadvantage in the short week, which adds to that.

New York Giants versus the Dallas Cowboys

It will be a classic NFC East rivalry matchup on Thanksgiving as the surprising New York Giants (7-3) travel to Dallas to take on the Cowboys (7-3). While the Giants and Cowboys have the same record, the Cowboys own a +84 point differential, while the Giants outscore their opponents by just one point.

Kickoff is scheduled for 4:25 PM ET Thursday. FOX will broadcast the game.

Dallas has won three of its four games since Dak Prescott returned to the lineup, but all four were against NFC North opponents. The lone loss came in overtime in Green Bay after the Cowboys blew a 14-point lead in the fourth quarter.

Cowboys running back Tony Pollard lead the NFL in explosive game speed with 14.1 percent of his touches for runs over 12 yards or receptions over 16 yards, according to TruMedia. Ezekiel Elliott returned to the lineup last week from a sprained knee and scored two touchdowns while Pollard got most of the running back work.

Daniel Jones and the Giants’ offense will have to contend with a Dallas defense that leads the league in pressure (42.7%). Saquon Barkley is still second in the NFL with 953 rushing yards despite a poor performance in Week 11.

New England Patriots versus Minnesota Vikings

It wouldn’t be Thanksgiving without football, right? The New England Patriots will face the NFC North-leading Minnesota Vikings to close out the three-game NFL holiday slate. Minnesota will enter the Week 12 contest as the small favorite.

The Vikings will stay home for the holidays when they host the Patriots at 8:20 p.m. ET Thursday at US Bank Stadium in Minneapolis on NBC. It will be Minnesota’s sixth time playing Minneapolis this season, which is a venue where first-year head coach Kevin O’Connell managed a 4-1 record. Whether the game is won with their offensive, defensive or specialty teams, the Vikings’ seven wins without defeat in single-score games this season should indicate that a close-score game could be their best chance to celebrate the Thanksgiving with a win.

How the defense performs could mean the difference between a Patriots win or loss. No one has managed to defeat New England this season when the Patriots are holding their opponents by 20 points. Matt Judon and the defense will have the challenge of trying to limit a Vikings offensive touch led by Kirk Cousins, Justin Jefferson and Dalvin Cook.

New England is 3-2 home and away. New England is 6-3-1 against the spread this season, while the under is 6-4 in games thus far. Minnesota is 8-2, but only 4-5-1 against the spread and the overs and unders are tied at 5-5.

(Photo by Ezekiel Elliott: Tom Pennington/Getty Images)


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