Research brings us closer to optimizing treatments for children with retinoblastoma

Retinoblastoma is an eye cancer that occurs in infants and young children and can lead to loss of vision, loss of one or both eyes, and even death. Unlike most cancers, these cannot be biopsied due to the risk of spreading the cancer to the rest of the body. In 2017, Jesse Berry, MD, eye … Read more

Prime Medicine spells out IPO plans for “word processor” or gene editing

Gene editing research is looking for more precise approaches, with the goal of avoiding off-target changes that cause problems in other parts of the genome. Prime Medicine aims to offer that precision along with the potential to address a wider range of genetic diseases. Biotechnology has yet to test this technology on patients, but it … Read more

Rejuvenate Bio CEO Highlights Ambitious Approach of Using Gene Therapy to Reverse Aging

Rejuvenate Bio is a gene therapy startup looking to reverse aging. In response to emailed questions, CEO and co-founder Daniel Oliver talked about how he and his co-founder started the company and their vision for treatment. age-related conditions. Why did you start this company? The idea was born in George Church’s laboratory at Harvard Medical … Read more

Transparency of laboratory testing will improve patient care and reduce costs

The need for understandable and transparent pricing for medical services in the United States has increased urgently with the continued rise in out-of-pocket healthcare costs. Americans are delaying health care because they are unsure of the cost or cannot afford it. A recent Willis Tower Watson (WTW) survey of 9,600 U.S. workers showed that 4 … Read more

Researchers join forces to “map” specific variations in more than 25 key heart disease genes

One in 100 people have genetic variations that can cause potentially life-threatening heart conditions, including high cholesterol (lipid disorders), heart muscle disease (cardiomyopathies), and abnormal heart rhythm (arrhythmias). Yet the functional impact of most of these cardiovascular genetic variants -; if they disrupt normal function or are harmless -; is unknown. This is about to … Read more

Tumor-infiltrating lymphocyte therapy treats tumors on a large scale

A new treatment strategy with personalized cell therapy significantly improves progression-free survival compared to standard immunotherapy in patients with advanced melanoma, according to the groundbreaking results reported at the ESMO 2022 Congress from the phase 3 M14TIL study. “This study shows for the first time in a randomized controlled trial that cell therapy can be … Read more

The study helps understand how dietary therapies for epilepsy work

Caloric restriction has long been associated with a reduction in seizures in epilepsy. New research from Boston Children’s Hospital helps explain how fasting affects neurons in the brain and could pave the way for new approaches that will avoid the need for fasting or restrictive diets. The results were published on August 30 in the … Read more

Using deep learning to guide chemotherapy selection after surgery for colorectal cancer patients

Among patients with colorectal cancer spread to the lymph nodes, a deep learning marker can identify a third with excellent prognosis and consequently without the need for adjuvant chemotherapy. Dual-agent chemotherapy is the current standard of care for these patients and can cause severe side effects and even death. New research shows how deep learning … Read more

New startup Versant Ventures has no guts for next-generation gene delivery

One of the reasons engineered viruses are used to deliver genetic medicines is that viruses are very good at penetrating cells. But the adeno-associated viruses (AAVs) used today have drawbacks. They have a limited genetic load capacity. Circulating in the body, they preferentially go to certain tissues or away from others. These viruses can also … Read more

CHOP helps launch a new computational platform to harmonize pediatric cancer data

The Children’s Hospital of Philadelphia (CHOP) has helped launch a new computational platform that will harmonize pediatric cancer data, enabling researchers, pharmaceutical companies and advocacy groups to accelerate the pace of pediatric cancer drug development. With funding from the National Cancer Institute (NCI) through a subcontract with Leidos Biomedical Research, current operator of NCI’s Frederick … Read more