The FDA approves the Taiho drug for rare bile duct cancer with a certain genetic signature

A Taiho Oncology drug for bile duct cancer is now approved by the FDA, providing a new treatment option for patients with advanced disease. The regulatory decision makes the Taiho drug the third approved product for such cancers driven by a particular genetic signature, but the manufacturer claims its cancer therapy has an advantage over … Read more

This gene therapy company is testing new technology to “turn off” diabetes and obesity with a pill

What if people who need regular injections to treat chronic diseases could instead take a pill that precisely controls the production of the right proteins and hormones within their bodies? A promising new gene therapy technology that aims to turn the human body into such a drug factory could, if successful, push the boundaries of … Read more

Prime Medicine spells out IPO plans for “word processor” or gene editing

Gene editing research is looking for more precise approaches, with the goal of avoiding off-target changes that cause problems in other parts of the genome. Prime Medicine aims to offer that precision along with the potential to address a wider range of genetic diseases. Biotechnology has yet to test this technology on patients, but it … Read more

Shape-changing fat cells fuel the growth of breast cancer

Newswise – Fat cells, or adipocytes, that grow in proximity to breast cancer can move to other types of tumor-promoting cell types, a new study by UT Southwestern researchers suggests. The findings, published in Cell Reports, could lead to new ways to fight breast cancer, a disease that is diagnosed in more than 300,000 US … Read more

Rejuvenate Bio CEO Highlights Ambitious Approach of Using Gene Therapy to Reverse Aging

Rejuvenate Bio is a gene therapy startup looking to reverse aging. In response to emailed questions, CEO and co-founder Daniel Oliver talked about how he and his co-founder started the company and their vision for treatment. age-related conditions. Why did you start this company? The idea was born in George Church’s laboratory at Harvard Medical … Read more

Transparency of laboratory testing will improve patient care and reduce costs

The need for understandable and transparent pricing for medical services in the United States has increased urgently with the continued rise in out-of-pocket healthcare costs. Americans are delaying health care because they are unsure of the cost or cannot afford it. A recent Willis Tower Watson (WTW) survey of 9,600 U.S. workers showed that 4 … Read more

Scientists from UT Southwestern identify genetic mutations that contribute to nonalcoholic fatty liver disease

Using a genetic screening platform developed by a UT Southwestern Nobel laureate, scientists from the Center for the Genetics of Host Defense at UT Southwestern Medical Center have identified genetic mutations that contribute to nonalcoholic fatty liver disease (NAFLD) , providing a potential future target for intervention therapy. Although obesity and diabetes are well-known risk … Read more

The brain and the fat communicate directly

With increasing rates of obesity and related metabolic diseases reported around the world, researchers have struggled to understand the functional status of adipose tissue in the body in relation to overall energy homeostasis. A new Nature the study examines the sensory innervation of fat cells within subcutaneous fat deposits, outlining the anatomical and functional effects … Read more

Abdominal obesity increases the risk of pancreatic cancer

Epidemiological evidence based on observational studies has revealed that type 2 diabetes (T2D) and obesity are two of the major risk factors for pancreatic cancer. Pancreatic cancer is strange; however, it is associated with poor prognosis and survival rates. In a recent study under review in the European Journal of Human Genetics and currently available … Read more

New startup Versant Ventures has no guts for next-generation gene delivery

One of the reasons engineered viruses are used to deliver genetic medicines is that viruses are very good at penetrating cells. But the adeno-associated viruses (AAVs) used today have drawbacks. They have a limited genetic load capacity. Circulating in the body, they preferentially go to certain tissues or away from others. These viruses can also … Read more